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Current State of Heart Disease

Acute Cardiac Infarction and the Path Forward

Occurs in approximately 80,000 people in Japan each year

Acute myocardial infarction is a condition which occurs when the blood vessels (coronary arteries) of the heart become blocked, halting blood flow and causing necrosis of myocardial cells. This condition occurs in approximately 80,000 people in Japan and approximately 1 million people in the United States each year. Many people die from myocardial infarction, which often occurs suddenly, and this disease accounts for the majority of cases of heart-related pathologies and is second leading cause of death in Japan.

Patient suffering and increased medical costs due to onset of chronic heart failure

*1 Japan Cardiovascular Society. “2017 (implemented/published in 2018) Cardiovascular Disease Medical Care Survey Report; Web Version”.
*2 MS&T Consulting investigation materials (survey materials requested by Adriakaim).
*3 *1 and Adriakaim calculated by Adriakaim based on data from Reference *1 and the “Trend of Westernization of Etiology and Clinical Characteristics of Heart Failure Patients in Japan-First Report From the CHART-2 Study”.
*4 Calculated by Adriakaim based on data from Reference *2.
*5 Central Medical Abstracts Database (Chuikyo). “Answers from 106 Experts: Heart Failure Treatment Q&A” (2012), “Epidemiology of Chronic Heart Failure” Miyuki Makaya and Hiroyuki Tsutsui.
*6 American Heart Association “Circulation: Heart Failure” (2013).

Everyday Living with Heart Failure Episodes

Adriakaim’s Efforts to Control Heart Failure

Heart disease is the second leading cause of death in Japan after cancer *7, and the leading cause of death in populations around the world, including the United States *8.
Despite the prescription of pharmacological therapies such as sympathetic nerve depressants and hormone depressants, approximately 30% of myocardial infarction patients in Japan and the United States *9 develop severe heart failure. Many cases of heart failure prove refractory after onset, and from the patient’s perspective, ease of both Activities of Daily Living (ADL) and Quality of Life (QOL) decline, resulting in not only increased anxiety in their everyday lives in the future, but also the incurring of enormous medical expenses every year.

*7 Japan Ministry of Health, Labour and Welfare. "Demographic Statistics” (2018).
*8 World Health Organization. “The top 10 causes of death” (2016).
*9 Academic Committee Joint Research Group, Japan Cardiovascular Society. “Guidelines for the Diagnosis and Treatment of Cardiovascular Diseases (2010 Joint Research Group Report); Acute Heart Failure Treatment Guidelines (2011 Revised Edition)”.